资源类型

期刊论文 1265

年份

2023 28

2022 31

2021 46

2020 73

2019 979

2018 11

2017 11

2016 10

2015 10

2014 9

2013 5

2012 5

2011 4

2010 10

2009 7

2008 2

2007 3

2005 1

2004 1

2000 1

展开 ︾

关键词

COVID-19 15

新冠病毒肺炎 11

“一带一路” 9

人工智能 8

中药 7

SARS-CoV-2 5

可持续发展 5

癌症 5

食物安全 5

临床试验 4

人才培养 4

工程成就 4

智能制造 4

临床特征 3

乡村规划 3

医学教育 3

安全性 3

新型冠状病毒肺炎 3

展开 ︾

检索范围：

排序： 展示方式：

Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

《医学前沿（英文）》 2020年 第14卷 第2期   页码 126-135 doi: 10.1007/s11684-020-0767-8

摘要： Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a significant threat to global health. It caused a total of 80 868 confirmed cases and 3101 deaths in Chinese mainland until March 8, 2020. This novel virus spread mainly through respiratory droplets and close contact. As disease progressed, a series of complications tend to develop, especially in critically ill patients. Pathological findings showed representative features of acute respiratory distress syndrome and involvement of multiple organs. Apart from supportive care, no specific treatment has been established for COVID-19. The efficacy of some promising antivirals, convalescent plasma transfusion, and tocilizumab needs to be investigated by ongoing clinical trials.

关键词： coronavirus disease 2019     epidemiology     pathology     radiology     clinical characteristics     treatment    

HTML PDF 收藏

Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from

Zhengqian Li, Taotao Liu, Ning Yang, Dengyang Han, Xinning Mi, Yue Li, Kaixi Liu, Alain Vuylsteke, Hongbing Xiang, Xiangyang Guo

《医学前沿（英文）》 2020年 第14卷 第5期   页码 533-541 doi: 10.1007/s11684-020-0786-5

摘要： Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a global pandemic in only 3 months. In addition to major respiratory distress, characteristic neurological manifestations are also described, indicating that SARS-CoV-2 may be an underestimated opportunistic pathogen of the brain. Based on previous studies of neuroinvasive human respiratory coronaviruses, it is proposed that after physical contact with the nasal mucosa, laryngopharynx, trachea, lower respiratory tract, alveoli epithelium, or gastrointestinal mucosa, SARS-CoV-2 can induce intrinsic and innate immune responses in the host involving increased cytokine release, tissue damage, and high neurosusceptibility to COVID-19, especially in the hypoxic conditions caused by lung injury. In some immune-compromised individuals, the virus may invade the brain through multiple routes, such as the vasculature and peripheral nerves. Therefore, in addition to drug treatments, such as pharmaceuticals and traditional Chinese medicine, non-pharmaceutical precautions, including facemasks and hand hygiene, are critically important.

关键词： coronavirus disease 2019 (COVID-19)     SARS-CoV-2     neurological manifestations     neuroinvasion     brain    

HTML PDF 收藏

Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19-19 in Wuhan

Li Ni, Ling Zhou, Min Zhou, Jianping Zhao, Dao Wen Wang

《医学前沿（英文）》 2020年 第14卷 第2期   页码 210-214 doi: 10.1007/s11684-020-0757-x

摘要： In December 2019, an outbreak of novel coronavirus (2019-nCoV) occurred in Wuhan, Hubei Province, China. By February 14, 2020, it has led to 66 492 confirmed patients in China and high mortality up to ~2.96% (1123/37 914) in Wuhan. Here we report the first family case of coronavirus disease 2019 (COVID-19) confirmed in Wuhan and treated using the combination of western medicine and Chinese traditional patent medicine Shuanghuanglian oral liquid (SHL). This report describes the identification, diagnosis, clinical course, and management of three cases from a family, suggests the expected therapeutic effects of SHL on COVID-19, and warrants further clinical trials.

关键词： novel coronavirus (2019-nCoV)     COVID-19     Chinese traditional patent medicine     Shuanghuanglian oral liquid    

HTML PDF 收藏

Organ function support in patients with coronavirus disease 2019: Tongji experience

Peng Chen, Shuiming Guo, Binhao Zhang, Xiaoning Wan, Wei Zhu, on behalf of Multidisciplinary Team for COVID-19-19, Optical Valley Branch of Tongji Hospital, Tongji Medical College, Huazhong University of Science

《医学前沿（英文）》 2020年 第14卷 第2期   页码 232-248 doi: 10.1007/s11684-020-0774-9

摘要： Coronavirus disease 2019 (COVID-19) is a highly contagious disease and a serious threat to human health. COVID-19 can cause multiple organ dysfunction, such as respiratory and circulatory failure, liver and kidney injury, gastrointestinal dysfunction, disseminated intravascular coagulation, and thromboembolism, and even death. The World Health Organization reports that the mortality rate of severe-type COVID-19 is over 50%. Currently, the number of severe cases worldwide has increased rapidly, but the experience in the treatment of infected patients is still limited. Given the lack of specific antiviral drugs, multi-organ function support treatment is important for patients with COVID-19. To improve the cure rate and reduce the mortality of patients with severe- and critical-type COVID-19, this paper summarizes the experience of organ function support in patients with severe- and critical-type COVID-19 in Optical Valley Branch of Tongji Hospital, Wuhan, China. This paper systematically summarizes the procedures of functional support therapies for multiple organs and systems, including respiratory, circulatory, renal, gastrointestinal, hepatic, and hematological systems, among patients with severe- and critical-type COVID-19. This paper provides a clinical reference and a new strategy for the optimal treatment of COVID-19 worldwide.

关键词： COVID-19     severe and critical type     organ function support    

HTML PDF 收藏

COVID-19 containment: China provides important lessons for global response

Shuxian Zhang, Zezhou Wang, Ruijie Chang, Huwen Wang, Chen Xu, Xiaoyue Yu, Lhakpa Tsamlag, Yinqiao Dong, Hui Wang, Yong Cai

《医学前沿（英文）》 2020年 第14卷 第2期   页码 215-219 doi: 10.1007/s11684-020-0766-9

摘要： The world must act fast to contain wider international spread of the epidemic of COVID-19 now. The unprecedented public health efforts in China have contained the spread of this new virus. Measures taken in China are currently proven to reduce human-to-human transmission successfully. We summarized the effective intervention and prevention measures in the fields of public health response, clinical management, and research development in China, which may provide vital lessons for the global response. It is really important to take collaborative actions now to save more lives from the pandemic of COVID-19.

关键词： coronavirus disease 2019 (COVID-19)     control measure     public health response    

HTML PDF 收藏

Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China

《医学前沿（英文）》 doi: 10.1007/s11684-023-1043-5

摘要： Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported at the end of 2019 as a worldwide health concern causing a pandemic of unusual viral pneumonia and many other organ damages, which was defined by the World Health Organization as coronavirus disease 2019 (COVID-19). The pandemic is considered a significant threat to global public health till now. In this review, we have summarized the lessons learnt during the emergence and spread of SARS-CoV-2, including its prototype and variants. The overall clinical features of variants of concern (VOC), heterogeneity in the clinical manifestations, radiology and pathology of COVID-19 patients are also discussed, along with advances in therapeutic agents.

关键词： coronavirus disease 2019     SARS-CoV-2     epidemiology     clinical features    

HTML PDF 收藏

Clinical characteristics of 19 neonates born to mothers with COVID-19

Wei Liu, Jing Wang, Wenbin Li, Zhaoxian Zhou, Siying Liu, Zhihui Rong

《医学前沿（英文）》 2020年 第14卷 第2期   页码 193-198 doi: 10.1007/s11684-020-0772-y

摘要： The aim of this study was to investigate the clinical characteristics of neonates born to SARS-CoV-2 infected mothers and increase the current knowledge on the perinatal consequences of COVID-19. Nineteen neonates were admitted to Tongji Hospital from January 31 to February 29, 2020. Their mothers were clinically diagnosed or laboratory-confirmed with COVID-19. We prospectively collected and analyzed data of mothers and infants. There are 19 neonates included in the research. Among them, 10 mothers were confirmed COVID-19 by positive SARS-CoV-2 RT-PCR in throat swab, and 9 mothers were clinically diagnosed with COVID-19. Delivery occurred in an isolation room and neonates were immediately separated from the mothers and isolated for at least 14 days. No fetal distress was found. Gestational age of the neonates was 38.6±1.5 weeks, and average birth weight was 3293±425 g. SARS-CoV-2 RT-PCR in throat swab, urine, and feces of all neonates were negative. SARS-CoV-2 RT-PCR in breast milk and amniotic fluid was negative too. None of the neonates developed clinical, radiologic, hematologic, or biochemical evidence of COVID-19. No vertical transmission of SARS-CoV-2 and no perinatal complications in the third trimester were found in our study. The delivery should occur in isolation and neonates should be separated from the infected mothers and care givers.

关键词： coronavirus disease 2019     severe acute respiratory syndrome-associated coronavirus     maternal-infant infection     newborn    

HTML PDF 收藏

China’s local governments are combating COVID-19 with unprecedented responses – from a Wenzhou governance

Fanghua Gong, Yong Xiong, Jian Xiao, Li Lin, Xiaodong Liu, Dezhong Wang, Xiaokun Li

《医学前沿（英文）》 2020年 第14卷 第2期   页码 220-224 doi: 10.1007/s11684-020-0755-z

摘要： The COVID-19 caused by a novel strain of coronavirus has been spreading rapidly since its onset in Wuhan, the capital city of central China’s Hubei Province, in December 2019. It is highly communicable through human-to-human transmission. China has been making unprecedented efforts in treating the confirmed cases, identifying and isolating their close contacts and suspected cases to control the source of infection and cut the route of transmission. China’s devotion in handling this epidemic has effectively and efficiently curbed communication domestically and across the border. Representative measures adopted by Wenzhou, the worst hit city out of Hubei Province, are examined to elucidate those massive undertakings with the aim of enhancing international understanding and building global rapport in fighting this evolving epidemic situation.

关键词： COVID-19     novel coronavirus pneumonia     2019-nCoV     epidemic management    

HTML PDF 收藏

COVID-19 疫情背景下的医院人工智能快速布局和发展战略探讨

陈新华,蒋建文,周华,谢海洋,周琳,郭丹婧,薛晨,朱威威,周建英,郑树森

《中国工程科学》 2020年 第22卷 第2期   页码 130-137 doi: 10.15302/J-SSCAE-2020.02.021

摘要：

本文旨在开展新型冠状病毒肺炎（COVID-19）疫情背景下医院人工智能（AI）应用的宏观探讨，以期推动我国医院AI应用的顶层设计和快速布局COVID-19疫情发生以来，中国以举国之力实施疫情防控阻击战，同步以捐赠物资、派遣医疗队、分享医疗诊治经验和高科技手段等方式开展全球抗疫协作。在抗击COVID-19疫情的过程中，一线医疗工作展示了有关医疗AI应用丰富且宝贵的经验，体现了AI在抗疫前线发挥的突出作用，表明了我国医院AI建设需求的迫切性和战略性。

关键词： 医院建设     新型冠状病毒肺炎     人工智能     应用现状     发展方向    

HTML PDF 收藏

中药治疗新冠病毒肺炎的科学基础 Perspective

梁丽娴, 潘胡丹, 黄虞枫, 范星星, 王婉莹, 何芳, 蔡俊, 周华, 刘良

《工程（英文）》 2020年 第6卷 第10期   页码 1099-1107 doi: 10.1016/j.eng.2020.08.009

摘要：

新近暴发的新冠病毒肺炎（COVID-19）已成为危害全球健康的紧急事件。现有证据表明，新冠病毒（SARS-CoV-2）与其他冠状病毒（如SARS-CoV和MERS-CoV）的基因序列具有相似性。COVID-19患者的临床病理特征提示患者在病情进展过程中通常会经历五个发展阶段：大量病毒感染、免疫系统抑制、细胞因子风暴、多器官损伤及后期的肺纤维化样改变， 严重者常导致死亡。但是，目前尚无针对COVID-19的 特效药物或疫苗，世界卫生组织（WHO）正敦促尽快建立新型预防和治疗策略。本文总结了此次抗疫过程中中国国家和省级机构推荐使用的中药复方和中成药的潜在用途和治疗机制，以期发现其治疗COVID-19的潜在科学内涵。

关键词： COVID-19     SARS-CoV-2     中药     抗病毒     细胞因子风暴     肺纤维化    

HTML PDF 收藏

Innovation-driven trend shaping COVID-19 vaccine development in China

《医学前沿（英文）》 doi: 10.1007/s11684-023-1034-6

摘要： Confronted with the coronavirus disease 2019 (COVID-19) pandemic, China has become an asset in tackling the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission and mutation, with several innovative platforms, which provides various technical means in this persisting combat. Derived from collaborated researches, vaccines based on the spike protein of SARS-CoV-2 or inactivated whole virus are a cornerstone of the public health response to COVID-19. Herein, we outline representative vaccines in multiple routes, while the merits and plights of the existing vaccine strategies are also summarized. Likewise, new technologies may provide more potent or broader immunity and will contribute to fight against hypermutated SARS-CoV-2 variants. All in all, with the ultimate aim of delivering robust and durable protection that is resilient to emerging infectious disease, alongside the traditional routes, the discovery of innovative approach to developing effective vaccines based on virus properties remains our top priority.

关键词： SARS-CoV-2     COVID-19 vaccine     vaccine development    

HTML PDF 收藏

A review of the safety and efficacy of current COVID-19 vaccines

《医学前沿（英文）》 2022年 第16卷 第1期   页码 39-55 doi: 10.1007/s11684-021-0893-y

摘要： Vaccination is the most effective and feasible way to contain the coronavirus disease 2019 (COVID-19) pandemic. The rapid development of effective COVID-19 vaccines is an extraordinary achievement. This study reviewed the efficacy/effectiveness, immunogenicity, and safety profile of the 12 most progressed COVID-19 vaccines and discussed the challenges and prospects of the vaccine-based approaches in a global crisis. Overall, most of the current vaccines have shown safety and efficacy/effectiveness during actual clinical trials or in the real-world studies, indicating a development of pandemic control. However, many challenges are faced by pandemic control in terms of maximizing the effect of vaccines, such as rapid vaccine coverage, strategies to address variants with immune escape capability, and surveillance of vaccine safety in the medium- and long-terms.

关键词： COVID-19     SARS-CoV-2     vaccine     safety     efficacy     effectiveness     immunogenicity    

HTML PDF 收藏

Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19

Xiaofang Cai, Hanlan Jiang, Simin Zhang, Shengying Xia, Wenhui Du, Yaoling Ma, Tao Yu, Wenbin Li

《医学前沿（英文）》 2020年 第14卷 第6期   页码 776-785 doi: 10.1007/s11684-020-0820-7

摘要： Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has spread around the world. However, approaches to distinguish COVID-19 from pneumonia caused by other pathogens have not yet been reported. We retrospectively analyzed the clinical data of 97 children with probable COVID-19. A total of 13 (13.4%) patients were confirmed positive for SARS-CoV-2 infection by nucleic acid RT-PCR testing, and 41 (42.3%) patients were found to be infected with other pathogens. Notably, no pathogen was detected in 43 (44.3%) patients. Among all patients, 25 (25.8%) had familial cluster exposure history, and 52 (53.6%) had one or more coexisting conditions. Fifteen (15.5%) patients were admitted or transferred to the PICU. In the 11 confirmed COVID-19 cases, 5 (45.5%) and 7 (63.6%) were positive for IgM and IgG against SARS-CoV-2, respectively. In 22 patients with suspected COVID-19, 1 (4.5%) was positive for IgG but negative for IgM. The most frequently detected pathogen was (29, 29.9%). One patient with confirmed COVID 19 died. Our results strongly indicated that the detection of asymptomatic COVID 19 or coexisting conditions must be strengthened in pediatric patients. These cases may be difficult to diagnose as COVID-19 unless etiologic analysis is conducted. A serologic test can be a useful adjunctive diagnostic tool in cases where SARS-CoV-2 infection is highly suspected but the nucleic acid test is negative.

关键词： coronavirus disease 2019     pediatrics     emergency     retrospective investigation     severe acute respiratory syndrome coronavirus 2    

HTML PDF 收藏

Comparison of the clinical features and therapeutics of COVID-19 in cardio-cerebrovascular disease (CCVD

Yu Wang, Lan Li, Yuanjiang Pan, Yu He, Zuhua Chen, Yunhao Xun, Yuhan Xu, Yilei Guo, Jiehong Yang, Jianchun Guo, Haitong Wan

《医学前沿（英文）》 2021年 第15卷 第4期   页码 629-637 doi: 10.1007/s11684-020-0825-2

摘要： Cardio-cerebrovascular disease (CCVD) is a major comorbidity of coronavirus disease 2019 (COVID-19). However, the clinical characteristics and outcomes remain unclear. In this study, 102 cases of COVID-19 from January 22, 2020 to March 26, 2020 in Xixi Hospital of Hangzhou were included. Twenty cases had pre-existing CCVD. Results showed that compared with non-CCVD patients, those with CCVD are more likely to develop severe disease (15% versus 1%), and the proportion of pneumonia severity index grade IV was significantly higher (25% versus 3.6%). Computed tomography images demonstrated that the proportion of multiple lobe lesion involvement was significantly higher in the CCVD group than in the non-CCVD group (90% versus 63.4%). Compared with non-CCVD group, the levels of C-reactive protein, fibrinogen, D-dimer, and serum amyloid-A were higher, whereas the total protein and arterial partial PaO were lower in the CCVD group. Although no statistical difference was observed in the outcomes between groups, CCVD patients received more intensive comprehensive treatment to improve COVID-19 symptoms compared with non-CCVD patients. Integrated Chinese and Western medicine treatments have certain advantages in controlling the severe conversion rate and mortality of COVID-19. In addition, given that COVID-19 patients are usually related to coagulation disorders and thrombosis risk, the application of Chinese medicine in promoting blood circulation and removing stasis should be strengthened.

关键词： COVID-19     cardio-cerebrovascular disease     traditional Chinese medicine     clinical features     clinical therapeutics    

HTML PDF 收藏

预测新型冠状病毒肺炎患者临床预后好转概率的列线图—— 以中国浙江省为例 Article

谢娇娇, 石鼎, 鲍明阳, 胡潇逸, 吴文瑞, 盛吉芳, 徐凯进, 王清, 吴静静, 王恺岑, 方戴琼, 李雅婷, 李兰娟

《工程（英文）》 2022年 第8卷 第1期   页码 122-129 doi: 10.1016/j.eng.2020.05.014

摘要：

本研究旨在为临床医生开发一种定量方法，以预测新型冠状病毒肺炎（COVID-19）患者临床预后好转的可能性。本研究收集了2020年1月10日至2月26日入院后经实验室确诊的104例COVID-19感染患者的数据，包括患者的临床基本信息和实验室检查结果，并比较好转和未好转患者的各项参数。本研究构建的列线图有助于临床医生预测每位COVID-19患者的临床预后好转的可能性，将有助于个性化的咨询和治疗。

关键词： 新型冠状病毒肺炎（COVID-19）     列线图     临床预后    

HTML PDF 收藏

标题 作者 时间 类型 操作

Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

期刊论文

Neurological manifestations of patients with COVID-19: potential routes of SARS-CoV-2 neuroinvasion from

Zhengqian Li, Taotao Liu, Ning Yang, Dengyang Han, Xinning Mi, Yue Li, Kaixi Liu, Alain Vuylsteke, Hongbing Xiang, Xiangyang Guo

期刊论文

Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19-19 in Wuhan

Li Ni, Ling Zhou, Min Zhou, Jianping Zhao, Dao Wen Wang

期刊论文

Organ function support in patients with coronavirus disease 2019: Tongji experience

Peng Chen, Shuiming Guo, Binhao Zhang, Xiaoning Wan, Wei Zhu, on behalf of Multidisciplinary Team for COVID-19-19, Optical Valley Branch of Tongji Hospital, Tongji Medical College, Huazhong University of Science

期刊论文

COVID-19 containment: China provides important lessons for global response

Shuxian Zhang, Zezhou Wang, Ruijie Chang, Huwen Wang, Chen Xu, Xiaoyue Yu, Lhakpa Tsamlag, Yinqiao Dong, Hui Wang, Yong Cai

期刊论文

Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China

期刊论文

Clinical characteristics of 19 neonates born to mothers with COVID-19

Wei Liu, Jing Wang, Wenbin Li, Zhaoxian Zhou, Siying Liu, Zhihui Rong

期刊论文

China’s local governments are combating COVID-19 with unprecedented responses – from a Wenzhou governance

Fanghua Gong, Yong Xiong, Jian Xiao, Li Lin, Xiaodong Liu, Dezhong Wang, Xiaokun Li

期刊论文

COVID-19 疫情背景下的医院人工智能快速布局和发展战略探讨

陈新华,蒋建文,周华,谢海洋,周琳,郭丹婧,薛晨,朱威威,周建英,郑树森

期刊论文

中药治疗新冠病毒肺炎的科学基础

梁丽娴, 潘胡丹, 黄虞枫, 范星星, 王婉莹, 何芳, 蔡俊, 周华, 刘良

期刊论文

Innovation-driven trend shaping COVID-19 vaccine development in China

期刊论文

A review of the safety and efficacy of current COVID-19 vaccines

期刊论文

Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19

Xiaofang Cai, Hanlan Jiang, Simin Zhang, Shengying Xia, Wenhui Du, Yaoling Ma, Tao Yu, Wenbin Li

期刊论文

Comparison of the clinical features and therapeutics of COVID-19 in cardio-cerebrovascular disease (CCVD

Yu Wang, Lan Li, Yuanjiang Pan, Yu He, Zuhua Chen, Yunhao Xun, Yuhan Xu, Yilei Guo, Jiehong Yang, Jianchun Guo, Haitong Wan

期刊论文

预测新型冠状病毒肺炎患者临床预后好转概率的列线图—— 以中国浙江省为例

谢娇娇, 石鼎, 鲍明阳, 胡潇逸, 吴文瑞, 盛吉芳, 徐凯进, 王清, 吴静静, 王恺岑, 方戴琼, 李雅婷, 李兰娟

期刊论文